The pupils are the visible windows into your autonomic nervous system
Mission Statement
The Clinical Neuro-Optic Research Initiative (CNRI) advances the science of pupil-based neurodiagnostics by preserving historic clinical insights, developing modern analytic tools, and conducting rigorous research that explores the relationship between ocular micro-structures and systemic health. Our mission is to validate and expand neuro-optic biomarkers that can support future breakthroughs in early detection, monitoring, and non-invasive assessment of autonomic and neurological function.
Vision
CNRI envisions a future in which standardized neuro-optic biomarkers complement mainstream clinical assessment, enabling earlier detection of health imbalances, more personalized care, and a deeper understanding of the body’s autonomic responses. We aim to become a trusted research institution that bridges historical clinical investigations with modern scientific rigor, ensuring that decades of prior work are not lost but elevated, validated, and expanded using contemporary technology.
Features
PupilMetrics features dark-adapted baseline recording, single-trial PLR protocols with calibrated flashes, and three-trial habituation sequences. It uses hybrid computer vision and machine-learning models for precise pupil/iris tracking, 5-point median smoothing, ellipse fitting, and boundary analysis to calculate key metrics such as baseline diameter, constriction amplitude, latency, constriction/redilatation velocities, and post-illumination pupil response (PIPR). Additional features include bilateral eye comparison for anisocoria detection, PLR grading (A–F), cross-trial waveform overlays, serial trend monitoring, and a fully local SQLite database with on-device processing for complete data privacy.
Organization
Building on decades of pioneering clinical observations conducted in Russia and Korea during the 1980s–1990s, CNRI integrates modern imaging, pattern recognition, and data-driven methodologies to investigate how subtle pupil irregularities may reflect underlying autonomic and neurological function. CNRI conducts non-invasive human studies, develops analytic frameworks, and collaborates with international researchers to explore the emerging field of neuro-optic biomarkers.
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